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Email:
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ivan.tkac@upjs.sk |
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Homepage:
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https://www.upjs.sk/LF/zamestnanec/ivan.tkac | |
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Faculty:
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LF UPJŠ
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Pavol Jozef Šafárik University in Košice Faculty of Medicine
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Department:
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4. IK
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4th Department of Internal Medicine
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Office:
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Phone:
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Faculty:
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LF UPJŠ
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Pavol Jozef Šafárik University in Košice Faculty of Medicine
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Department:
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4. IK
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4th Department of Internal Medicine
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Office:
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HE2O01 | |
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Phone:
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+421 55 234 3479 | |
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ORCID ID:
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0000-0002-3171-8803 |
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Overview of the responsibility for
the delivery, development and quality assurance of the study programme or its part
at the university in the current academic year
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Study programme: Internal Medicine 3, study field: General Medicine, I.-II. degree
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Profile courses
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Clinical and translational medicine - Internal Medicine, III degree
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Selected publications
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Javorský M, Gotthardová I, Klimčáková L, Kvapil M, Židzik J, Schroner Z, Doubravová P, Gaľa I, Dravecká I, Tkáč I. A missense variant in GLP1R gene is associated with the glycemic response to treatment with gliptins. Diabetes Obes Metab. 2016;18(9):941-944. IF 2018 6,133 (Endocrinology & Metabolism Q1) |
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Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Keoki William L, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L, MetGen investigators, DPP investigators, ACCORD investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER. Variation in the glucose transporter gene SLC2A2 is associated with glycaemic response to metformin. Nat Genet 2016;48(9):1055-1059. IF 2017 27.125 (Genetics & Heredity Q1). |
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Tkáč I, Raz I. Combined analysis of three large interventional trials with gliptins indicates increased incidence of acute pancreatitis in patients with type 2 diabetes. Diabetes Care 2017;40(2):284-286. IF 2020 19,112 (Endocrinology & Metabolism Q1). |
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Gotthardová I, Javorský M, Klimčáková L, Kvapil M, Schroner Z, Kozárová M, Malachovská M, Ürgeová A, Židzik J, Tkáč I. KCNQ1 gene polymorphism is associated with glycaemic response to treatment with DPP-4 inhibitors. Diabetes Res Clin Pract 2017;130:142-147. IF 2020 5,602 (Endocrinology & Metabolism Q1). |
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Schernthaner G, Karasik A, Abraitiené A, Ametov AS, Gaál Z, Gumprecht J, Janež A, Kaser S, Lalić K, Mankovsky BN, Moshkovich E, Past M, Prázný M, Radulian G, Smirčić Duvnjak L, Tkáč I, Trušinskis K. Evidence from routine clinical practice: EMPRISE provides a new perspective on CVOTs. Cardiovasc Diabetol 2019;18:115. IF 2020 9, 951 (Endocrinology & Metabolism Q1) |
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Selected projects
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VEGA 1/0027/16. Principal investigator. Monitoring associations of selected gene variants with response to oral antidiabetic drugs gliptins Evaluation: Goals fulfilled and excellent results achieved |
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VEGA 1/0183/20. Principal Investigator Monitoring of genomic and proteomic markers of atherosclerosis progression in limb and carotid artery atherosclerosis in type 2 diabetes Project ongoing 2020-2023 |
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APVV-16-0158. Co-investigator. 2017-2020 Obesity, sleep apnoea and obesity-hypoventilation syndrome: the effect of hypoxia on cardiovascular parameters in obesity-associated respiratory diseases and possibilities of their therapeutic influence |
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International mobilities and visits
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Research and clinical fellowship, University of Toronto, Canada, 1995-1998, Individual
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Organisational activities
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Guarantor of habilitation and inauguration in internal medicine - P.J. Šafárik University in Košice, 2014-2021
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Director of PhD study programme in internal medicine - P.J. Šafárik University in Košice, 2014-2021
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Director of specialty study programme in internal medicine - P.J. Šafárik University in Košice, 2017-2021
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Awards
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1990 Award of the Slovak Society of Internal Medicine for the best scientific publication of the year.
1990 Award of the Slovak Society of Diabetology for the best scientific publication of the year.1999 Servier Prize for Original Work in Diabetology awarded by the Committee of the Slovak Diabetological Society2000 Prize of the Slovak Diabetological Society for the best scientific publication of the year2004 Pfizer Prize awarded by the SDS Committee for the best publication in the field of lipidology2005 Servier Prize awarded by the SDS Committee for the best publication in the field of diabetes2006 Novo Nordisk Prize awarded by the SDS Committee for the best publication2007 Slovak Diabetes Society Prize for the best scientific publication of the year2016 Dérer Prize awarded by the President of the Slovak Medical Association. |
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Projects
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VEGA 1/0380/10. Principal investigator. Investigation of the influence of polymorphisms of candidate genes of type 2 diabetes mellitus on the effect of treatment with oral antidiabetic drugs from the groups of sulfonylurea derivatives and dipeptidyl peptidase 4 (DPP-4) inhibitors.
VEGA 1/0340/12. Principal Investigator. To investigate the effect of polymorphisms of genes affecting the pharmacokinetics and pharmacodynamics of metformin on the effect of metformin treatment in patients with type 2 diabetes.VEGA 1/0027/16. Principal Investigator. Monitoring associations of selected gene variants with response to treatment with oral antidiabetic drugs gliptin. Principal Investigator. Monitoring of genomic and proteomic markers of atherosclerosis progression in type 2 diabetes of the limb and carotid arteries Duration of solution: 2020 - 2023APVV-16-0158. Co-investigator. Obesity, sleep apnea and obesity-hypoventilation syndrome: the effect of hypoxia on cardiovascular parameters in obesity-associated respiratory diseases and therapeutic optionsAPVV-0134-11. Co-investigator. The role of hypoxia in the activation of molecular pathways associated with increased cardiovascular risk in patients with sleep apnea and their therapeutic implications |
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International collaboration
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Member of international research consortium MetGen PLUS which is focusing on the study of pharmacogenetics of treatment with antidiabetic drugs.
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Other
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- Co-author of the Recommendations for the Treatment of Diabetes Mellitus, chief editor of the Recommendations for the Treatment of Dyslipidaemia and Recommendations for the Diagnosis and Treatment of Metabolic Syndrome in the Slovak Republic. - Representative of Slovakia in the international group of experts in the field of diabetology based in Vienna: Diabetes International Research and Educational Collaborative Team (2002 - 2006). - Member of the Data Monitoring Committee of the multicentre worldwide HEART2D study, which investigated the effect of different types of insulin treatment on the incidence of cardiovascular complications of type 2 diabetes (2002 - 2007). - Member of the Abstract Review Committee for the European Society for the Study of Diabetes (EASD) congress in 2004 - Member of the editorial boards of Diabetes and Obesity - Deputy Chief Editor, Internal Medicine, Forum Diabetologicum, AtheroReview - Member of the EURODIA Expert Group, which developed the 7th European Diabetes Research Institute (EDI) with grant support. DIAMAP document outlining the main directions of diabetes research in the EU (2008-2010). - Expert of the Directorate for Science of the European Commission for the assessment of FP7 and Horizon 2020 grant proposals in the field of diabetes, obesity and atherosclerosis since 2010 - Member of the CoR of the Ministry of Health of the Slovak Republic, 2009-2011 - Member of the VEGA Commission No. 9 for medical and pharmaceutical sciences, from 2008-2012, Chairman of the Commission 2012-2014, Vice-Chairman 2014-2016.
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Hobbies
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Literature, movies, sport.
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