LF

RNDr. Martina Šemeláková, PhD.   SK

Email:
martina.semelakova@upjs.sk
Homepage:
https://www.upjs.sk/LF/zamestnanec/martina.semelakova
Faculty:
LF UPJŠ - Pavol Jozef Šafárik University in Košice Faculty of Medicine
Department:
ULBL - Department of Medical Biology
Office:
MA6O606
Phone:
+421 55 234 3337
ORCID ID:
0000-0002-0584-5331
Researcher at the Institute of Medical Biology. In 2016, she was awarded the Scientific Qualification Level IIa by the Slovak Academy of Sciences. She is the author / co-author of 23 original scientific papers (WOS / SCOPUS) (12 first-author works), cited 217 times. Has experience with several molecular biology analyzes, gene analyzes (DNA, RNA, PCR, qPCR, seqRNA analysis), gene region design, primers and sequencing analyzes, phylogenetic studies of different species of organisms (MEGA), gene variability, LC / MS methods, immunoprecipitations, protein analyzes, imaging of cell interactions by fluorescence microscopy, ChiP analyzes, many years of experience in culturing various tumor cells, culturing various bacterial species and genome, species identification, definition of cell proliferation and metabolic activity. Extensive experience in GMO preparation, transformation, transduction, transfection of genomes using retroviruses, letiviruses and bacterial cells. She completed a work placement at The Medical University of South Carolina Carolina, MUSC, Department of Cell and Molecular Pharmacology & Experimental Therapeutics, Hollings Cancer Center), in prof. Rosenzweig S.A., in Charleston, USA, where she gained experience in the field modern molecular and biological analyzes (the output is the article Šemeláková et al., Translational Oncology 2019). She carried out a working stay at a specialized workplace at the Rowett Research Institute, Aberdeen, Scotland (high citation articles: Regensbogenová M. (Šemeláková) et al., FEMS Microbiology Letters 2004; Letters in Applied Microbiology 2004; Acta Protozoologica 2004). Marie Curie fellowship, international ERCULE project (CORDIS QLRI-CT- 2000-01455, coordinated by UK, Rowett Research Institute, Aberdeen, Scotland, microbiological laboratory, and prof. Newbold J.C. Graduate of 2022 from the Fulbright Research and Research Lecture at Wistar Institute, Gene Expression and Regulation Program, Cancer Center, Philadelphia, USA. The Wistar Institute is one of the oldest research centers in the United States, where the first vaccines were developed: the measles, mumps and rubella (MMR) vaccine, the Zika virus vaccine, two Powassan virus vaccines, a rotavirus vaccine and others. She has been involved in solving a research role within the international lead biomedical research in cancer, immunology, infectious and vaccine development, where a new potential path is being sought for the development of a Epstein-Barr virus (EBV) therapist. In the past she was a co-investigator of 11 projects (VEGA, APVV) and leader of 1 VVGS project UPJŠ. It contributed to the GenBank database 747 DNA sequences, 158 protein sequences, thus provided data for the scientific community. Its scientific attention has been paid in recent years to the effect of bioactive compounds on metastasis, the antiangiogenic effect studied on the original and resistant adenocarcinoma colon, with a characterized membrane tumor cell profile and erythropoietin receptor role. Thanks to her rich work experience abroad, he provides students with an overview of the most modern methods used in the diagnosis of various diseases in the world. She is a trainer of graduates and doctoral students. Awarded European Cancer Research Association, EACR: https://www.eacr.org/news/image-of-the-month-july2017, NEDD9 protein study during SCC9 metastatic process shows high actin activation fibers on the surface of head and neck cancer cells.

Higher education and further qualification growth
First degree of higher education:
Pavol Jozef Safarik University in Kosice, 1998, Biology
Second degree of higher education:
Pavol Jozef Safarik University in Kosice, 2000, Molecular biology
Third degree of higher education:
Pavol Jozef Safarik University in Kosice, 2004, Genetics

Research /art/ teacher profile

Display details  
Profile courses
Biology 1 - General medicine, 1. and 2. level degree
Biology 2 - General medicine, 1. and 2. level degree
Biology 1 - Dental medicine, 1. and 2. level degree
Biology 2 - Dental medicine, 1. and 2. level degree
Methods in human genetics and molecular biology - General medicine, 1. and 2. level degree
Selected publications

ADC - Šemeláková M., Grauzam S., Betadthunga P., Tiedeken J., Coaxum S., Neskey D., Rosenzweig S. Vimentin and Non-Muscle Myosin IIA are Members of the Neural Precursor Cell Expressed Developmentally Down- Regulated 9 (NEDD9) Interactome in Head and Neck Squamous Cell Carcinoma Cell - Translational Oncology. - ISSN 1936-5233. - 12, č. 1 (2019): 49-61. IF 4.7, Q2, Cited: 5 times.

ADC - Šemeláková M., Sačková V., Fedoročko P. The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells (HT-29) - Anti-Cancer Drugs. 29:10 (2018) 983-994. IF 2.4, Q2. Cited: 1 times

ADC - Ševčovičová A, Šemeláková M, Plšíková J, Loderer D, Imreová P, Gálová E, Kožurková M, Miadoková E, Fedoročko P. DNA-protective activities of hyperforin and aristoforin. Toxicol In Vitro. (2015): 631-7. IF 3.338, Q2. Cited: 16-times

ADC - Šemeláková M., R. Jendželovský, P. Fedoročko - Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells - Biomedicine & Pharmacotherapy. ISSN 0753-3322. 81 (2016), 38-47. IF 4.5, Q2, Cited: 14 times

ADC- Tothova, Z, Semelakova M, Solarova, Z, Tomc, J, Debeljak, N, Solar P. The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization International Journal of Molecular Sciences (2021) 22 (14) No7682. IF 5.924, Q1. Cited: 1 times

Selected projects

VEGA 1/0536/19. Úloha erytropoetínového receptora v odpovedi buniek adenokarcinómu mliečnej žľazy na paklitaxel v podmienkach in vitro a in vivo. / researcher

VEGA1/0147/15. Pleiotropné pôsobenie neaktivovaného alebo fotodynamicky aktívneho hypericínu na faktory ovplyvňujúce rezistenciu nádorových buniek / researcher

APVV-14-0154.Transkriptóm, metabolóm a signalóm bioaktívnych látok s protinádorovým účinkom v rode Hypericum/ researcher

International mobilities and visits
Rowett Research Institute, Aberdeen, Scotland, Maj - December 2002, Marie Curie fellowship
Medical University of South Carolina (MUSC), Hollings Cancer Center, Charleston, SC, USA, February - August 2014, fellow, Department of Cell and Molecular Pharmacology and Experimental Therapeutics
Charles University, Hospital Motol, Praha, CZ, 7 days / 2018, ERASMUS+
Reykjavik University, Reykjavik, Island, 7 days / 2019, ERASMUS+
Czech Academy of Sciences, UFHZ, Prague, CZ, 7 days / 2020, ERASMUS+
The Wistar Institute, Philadelphia, USA, 1.2.2022 - 31.7.2022, Fulbright program for research and lecturing
Organisational activities
ambassador, member of the professional society for cancer research - European Association for Cancer Research (EACR), 2015 - up to now

Additional information

Projects
VVGS - 132/2006, VEGA MŠ SR and SAV 1/2329/05, APVT-20-012104 APVT-20-003704, VVGS/001/2004/B, VVGS/007/2003/B, VVGS/027/2002/B, VEGA MŠ SR and SAV 1/9211/02, Bilateral initiative “Bilateral relations and common knowledge between Slovakia and Iceland research at Universities on topic “Genomic instability and cancer “GenICa” is implemented thanks to the financial support of Iceland, Liechtenstein and Norway through EEA and Norway Grant
International collaboration
Laboratory of Anaerobic Microbiology (LAM), AS CR
Other
H index = 8; publications 29 CC, 311 citations
Interesting links
https://magazine.eacr.org/eacr-image-of-the-month-october-2016-2017/ ORCID ID 0000-0002-0584-5331; https://www.webofscience.com/wos/woscc/citation-report/a162e96b-718d-42b7-922c-3c7ba3536ef8-d6d75c34 https://www.upjs.sk/lekarska-fakulta/en/actuality/upjs-in-kosice-received-grants-from-the-eea-and-norway/
Hobbies
travel, flowers, research

Further information


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