PF

RNDr. Adrián Gucký, PhD.   SK

Email:
adrian.gucky@upjs.sk
Homepage:
https://www.upjs.sk/PF/zamestnanec/adrian.gucky
Faculty:
PF UPJŠ - Pavol Jozef Šafárik University in Košice, Faculty of Science
Department:
ÚCHV - Institute of Chemistry
Office:
RB2O229
Phone:
+421 55 234 2661
Faculty:
PF UPJŠ - Pavol Jozef Šafárik University in Košice, Faculty of Science
Department:
ÚCHV - Institute of Chemistry
Office:
Phone:
ORCID ID:
0009-0002-0514-8592

Higher education and further qualification growth
First degree of higher education:
Pavol Jozef Šafárik University in Košice, 2019, Fields - Biology, Chemistry; Programme - Biology-Chemistry
Second degree of higher education:
Pavol Jozef Šafárik University in Košice, 2021, Field - Chemistry; Programme - Biochemistry
Third degree of higher education:
Pavol Jozef Šafárik University in Košice, 2025, Field - Chemistry; Programme - Biochemistry

Research /art/ teacher profile

Display details  
Profile courses
Biochemistry of microorganisms - Biochemistry, II. degree
Basic laboratory methods in chemistry - Chemical laboratory technician - specialist, I. degree
Selected publications

Hamuľaková S, Gucký A, Mezencev R, Kožurková M, Bednáriková Z, Marek J, Soukup O, Janoušek J, Gažová Z. Inhibition of amyloid fibrillization of amyloid β peptide by 4,7-disubstituted coumarin derivatives. Bioorg Med Chem. 2025;129:118302. DOI: 10.1016/j.bmc.2025.118302

Janovec L, Gucký A, Krochtová K, Michalková R, Kušnírová K, Miškufová V, Jáger D, Mojžiš J, Kožurková M. Development of 2,9-Disubstituted Acridines as Topoisomerase IIα Inhibitors with Strong Anticancer Activity: Synthesis, Biological Evaluation, and In Silico Study. ChemMedChem. 2025;20(15):e202500267. DOI: 10.1002/cmdc.202500267

Konkoľová E, Miháliková M, Nowak KE, Gucký A, Vilková M, Kožurková M. Studies of the Novel Bioactive Acridine-1,3-thiazolidin-4-one Derivatives With Human Serum Albumin Using Fluorescence Spectroscopy and Molecular Modelling. Luminescence. 2024;39(12):e70041. DOI: 10.1002/bio.70041

Rendošová M, Gyepes R, Gucký A, Kožurková M, Vilková M, Olejníková P, Kello M, Liška A, Kléri I, Havlíčková J, Tamáš A, Vargová Z. In(III) pyridinecarboxylate complexes: Composition, solution equilibria estimation, bioevaluation and interactions with HSA. J Inorg Biochem. 2025;262:112738. DOI: 10.1016/j.jinorgbio.2024.112738

Gucký A, Hamuľaková S. Targeting Biometals in Alzheimer's Disease with Metal Chelating Agents Including Coumarin Derivatives. CNS Drugs. 2024;38(7):507-532. DOI: 10.1007/s40263-024-01093-0

Selected projects

VEGA 1/0037/22: Development and research of novel acridine- and coumarin-based pharmacophores with antimicrobial and anticancer activities - participant

VEGA 1/0268/24: Novel antimicrobial peptides and metal ion heterocycles with biocompatible structure for the treatment of infections and tumors - participant

VEGA 1/0347/23: Non-canonical DNA structural motifs as a foundation for biosensoric nanoconjugates - participant

VVGS-2023-2553: Analysis of the anticancer potential of selected 4,7-disubstituted coumarin derivatives - participant

International mobilities and visits
Biomedical Research Centre, University Hospital Hradec Králové, 22nd of April 2024 - 3rd of May 2024

Further information


PF