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Email:
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adrian.gucky@upjs.sk | |
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Homepage:
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https://www.upjs.sk/PF/zamestnanec/adrian.gucky | |
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Faculty:
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PF UPJŠ
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Pavol Jozef Šafárik University in Košice, Faculty of Science
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Department:
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ÚCHV
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Institute of Chemistry
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Office:
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RB2O229 | |
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Phone:
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+421 55 234 2661 | |
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Faculty:
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PF UPJŠ
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Pavol Jozef Šafárik University in Košice, Faculty of Science
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Department:
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ÚCHV
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Institute of Chemistry
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Office:
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Phone:
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ORCID ID:
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0009-0002-0514-8592 |
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Profile courses
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Biochemistry of microorganisms - Biochemistry, II. degree
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Basic laboratory methods in chemistry - Chemical laboratory technician - specialist, I. degree
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Selected publications
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Hamuľaková S, Gucký A, Mezencev R, Kožurková M, Bednáriková Z, Marek J, Soukup O, Janoušek J, Gažová Z. Inhibition of amyloid fibrillization of amyloid β peptide by 4,7-disubstituted coumarin derivatives. Bioorg Med Chem. 2025;129:118302. DOI: 10.1016/j.bmc.2025.118302 |
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Janovec L, Gucký A, Krochtová K, Michalková R, Kušnírová K, Miškufová V, Jáger D, Mojžiš J, Kožurková M. Development of 2,9-Disubstituted Acridines as Topoisomerase IIα Inhibitors with Strong Anticancer Activity: Synthesis, Biological Evaluation, and In Silico Study. ChemMedChem. 2025;20(15):e202500267. DOI: 10.1002/cmdc.202500267 |
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Konkoľová E, Miháliková M, Nowak KE, Gucký A, Vilková M, Kožurková M. Studies of the Novel Bioactive Acridine-1,3-thiazolidin-4-one Derivatives With Human Serum Albumin Using Fluorescence Spectroscopy and Molecular Modelling. Luminescence. 2024;39(12):e70041. DOI: 10.1002/bio.70041 |
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Rendošová M, Gyepes R, Gucký A, Kožurková M, Vilková M, Olejníková P, Kello M, Liška A, Kléri I, Havlíčková J, Tamáš A, Vargová Z. In(III) pyridinecarboxylate complexes: Composition, solution equilibria estimation, bioevaluation and interactions with HSA. J Inorg Biochem. 2025;262:112738. DOI: 10.1016/j.jinorgbio.2024.112738 |
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Gucký A, Hamuľaková S. Targeting Biometals in Alzheimer's Disease with Metal Chelating Agents Including Coumarin Derivatives. CNS Drugs. 2024;38(7):507-532. DOI: 10.1007/s40263-024-01093-0 |
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Selected projects
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VEGA 1/0037/22: Development and research of novel acridine- and coumarin-based pharmacophores with antimicrobial and anticancer activities - participant |
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VEGA 1/0268/24: Novel antimicrobial peptides and metal ion heterocycles with biocompatible structure for the treatment of infections and tumors - participant |
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VEGA 1/0347/23: Non-canonical DNA structural motifs as a foundation for biosensoric nanoconjugates - participant |
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VVGS-2023-2553: Analysis of the anticancer potential of selected 4,7-disubstituted coumarin derivatives - participant |
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International mobilities and visits
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Biomedical Research Centre, University Hospital Hradec Králové, 22nd of April 2024 - 3rd of May 2024
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