1.ADC - ID: UPJŠ.Košice.000067526 Váhovská L., Potočňák I., Vitushkina S. & Walko M.: Low-dimensional compounds containing cyanido groups. Part XXX. Recrystallization of Co(II) complexes with pseudohalogenide ligands leading to CO2 uptake and formation of dicyanoguanidine anion in newly created Co(III) complexes. Polyhedron, 117, 359-366 (2016).

ADC - ID: UPJŠ.Košice.000068921 Farkasová V., Drweesh S. A., Lüköová A., Sabolová D., Radojević I. D., Čomić L. R., Vasić S. M., Paulíková H., Fečko S., Balašková T., Vilková M., Imrich J. & Potočňák I.: Low-dimensional compounds containing bioactive ligands. Part VIII: DNA interaction, antimicrobial and antitumor activities of ionic 5,7-dihalo-8-quinolinolato palladium(II) complexes with K+ and Cs+ cations. Journal of Inorganic Biochemistry, 167, 80-88 (2017).

ADC - ID: 65437 Váhovská L., Vitushkina S., Potočňák I., Trávníček Z. & Herchel R.: Effect of linear and non-linear pseudohalides on the structural and magnetic properties of Co(II) hexacoordinate single-molecule magnets. Dalton Transactions, 47, 1498-1512 (2018).

ADC - ID: 115087 Váhovská L., Bukrynov O., Potočňák I., Čižmár E., Kliuikov A., Vitushkina S., Dušek M. & Herchel R.: New Cobalt(II) Field-Induced Single-Molecule Magnet and the First Example of a Cobalt(III) Complex with Tridentate Binding of a Deprotonated 4-Amino-3,5-bis(pyridin-2-yl)-1,2,4-Triazole Ligand. European Journal of Inorganic Chemistry, 250–261 (2019).

ADC - ID: 190932 Litecká M., Hreusová M., Kašpárková J., Gyepes R., Smolková R., Obuch J., David T. & Potočňák I.: Low-dimensional compounds containing bioactive ligands. Part XIV: High selective antiproliferative activity of tris(5-chloro-8-quinolinolato)gallium(III) complex against human cancer cell lines. Bioorganic & Medicinal Chemistry Letters, 30 (2020) 127206.

APVV-18-0016, Agentúra na podporu výskumu a vývoja. Molecular nanomagnets composed of transition metal complexes.

07/19-06/23 Co-investigator of the project.

VEGA 1/0148/19, Vedecká grantová agentúra MŠVVaŠ SR a SAV. Complexes of platinum metals with planar aromatic nuclei as antitumor drugs.

01/19-12/22 Principal investigator.

The project encompasses a multi-stage synthesis of planar organic ligands that can intercalate into DNA. They

include derivatives of 8-hydroxyquinoline differing by substituents at positions 5,7 or 2, and coumarin and acridine

derivatives differing by a length of side chains and by donor atoms. An advanced synthesis of Pd(II), Pt(II), Ru(III)

and 3d metal complexes with prepared and commercially available ligands will follow. All compounds will be fully

characterized by physico-chemical methods, eventually by X-ray structural analysis, study of their interaction with

DNA by cell free techniques and their cytotoxic and antimicrobial activity against selected tumor lines and

bacteria strains, and antioxidant activity will follow. Our aim is to prepare cytotoxic compounds, which have a

different mode of interaction with tumor cells than cisplatin to reduce the side effects on the organism.

VEGA 1/0126/23, Vedecká grantová agentúra MŠVVaŠ SR a SAV.Antiproliferative complexes with bulky N- and O-donor aromatic ligands.

01/23-12/26 Principal investigator.

The scope of the project is the organic synthesis of aromatic ligands intercalating into DNA. These are a) 8-hydroxyquinoline derivatives differing in the substituents in positions 5 and 7, products of their oxidations and their subsequent condensation reactions, b) various amino derivatives of coumarin, c) substituted N-acylhydrazones of acridine and anthracene. Furthermore, an advanced synthesis of complexes with prepared ligands will be performed. All compounds will be completely characterized by physicochemical methods, X-ray structural analysis and then their interaction with DNA, cytotoxic and antimicrobial activity against selected tumor lines and microorganisms, and antioxidant activity will be studied. The aim of the project is to prepare cytotoxic substances that show a different way of interacting with tumor cells than cisplatin in order to reduce their side effects on the body. For paramagnetic complexes, their magnetic properties will also be studied with a focus on single-molecule magnetism.