PF

RNDr. Jana Vargová, PhD.   SK

Email:
jana.vargova@upjs.sk
Homepage:
https://www.upjs.sk/PF/zamestnanec/jana.vargova
Faculty:
PF UPJŠ - Pavol Jozef Šafárik University in Košice, Faculty of Science
Department:
ÚBEV - Institute of Biology and Ecology
Office:
RB1O102
Phone:
+421 55 234 1187
ORCID ID:
0000-0002-4066-3453
I have been working as a full-time research assistant at the Department of Cell Biology since 2018. In addition to teaching responsibilities (Stem Cell Biology, Introduction to Flow Cytometry, Seminar series in Cytology and Molecular Biology and others), I am engaged in research of cancer stem-like cells, the impact of hypoxia and natural substances on the resistant phenotype of cancer cells and epithelial to mesenchymal transition. Currently on maternity leave (from July 2024).

Higher education and further qualification growth
First degree of higher education:
University of Pavol Jozef Safarik in Kosice, 17.9.2007 – 27.8.2010, Programme: Biology; Field: Biology
Second degree of higher education:
University of Pavol Jozef Safarik in Kosice, 10.9.2010 – 22.5.2012, Programme: Genetics and Molecular Cytology; Study field: Biology
Third degree of higher education:
University of Pavol Jozef Safarik in Kosice, 3.9.2012 – 28.3.2018, Molecular Cytology; Study field: Biology

Research /art/ teacher profile

Display details  
Profile courses
Cytology (seminar series) - Biology, Biology-X, Biophysics, I. degree
Molecular biology (seminar series) - Biology, I. degree
Stem Cell Biology - Genetics and Molecular Cytology; Zoology and Animal Physiology, II. degree
Selected publications

Buľková V., Vargová J., Babinčák M., Jendželovský R., Zdráhal Z., Roudnický P., Košuth J., Fedoročko P. New findings on the action of hypericin in hypoxic cancer cells with a focus on the modulation of side population cells. In Biomedicine and Pharmacotherapy, 2023, 163, 114829.

Nagy Ľ., Zeleňáková A., Hrubovčák P., Barutiak M., Lisnichuk M., Bednarčík J., Vargová J., Jendželovský R., Ševc J., Vilček Š. The role of pH on the preparation of citric acid coated cobalt ferrite nanoparticles for biomedical applications. In Journal of Alloys and Compounds, 2023, 960,170833.

Majerník M., Jendželovský R., Vargová J., Jendželovská Z., Fedoročko P. Multifunctional Nanoplatforms as a Novel Effective Approach in Photodynamic Therapy and Chemotherapy, to Overcome Multidrug Resistance in Cancer. In Pharmaceutics, 2022, 14(5):1075.

Babinčák M., Jendželovský R., Košuth J., Majerník M., Vargová J., Mikulášek K., Zdráhal Z., Fedoročko P. Death Receptor 5 (TNFRSF10B) Is Upregulated and TRAIL Resistance Is Reversed in Hypoxia and Normoxia in Colorectal Cancer Cell Lines after Treatment with Skyrin, the Active Metabolite of Hypericum spp. In Cancers (Basel), 2021,13(7).

Konkoľová E., Hudáčová M., Hamuľaková S., Jendželovský R., Vargová J., Ševc J., Fedoročko P., Kožurková M. Tacrine-Coumarin Derivatives as Topoisomerase Inhibitors with Antitumor Effects on A549 Human Lung Carcinoma Cancer Cell Lines. In Molecules, 2021, 26(4):1133.

Hudáčová M, Hamuľaková S, Konkoľová E, Jendželovský R, Vargová J, Ševc J, Fedoročko P, Soukup O, Janočková J, Ihnatova V, Kučera T, Bzonek P, Novakova N, Jun D, Junova L, Korábečný J, Kuča K, Kožurková M. Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells. In Int J Mol Sci. 2021, 22(8):3830.

Nunhart P, Konkoľová E, Janovec L, Jendželovský R, Vargová J, Ševc J, Matejová M, Miltáková B, Fedoročko P, Kozurkova M. Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity. In Bioorg Chem., 2020, 94:103393.

Selected projects

EPIC-XS-0000051 (p.n. 823839, The European Proteomics Infrastructure Consortium providing access) funded by the Horizon 2020 programme of the European Union: ProSiPo (Proteomics of the Side Population): Comparative proteomic analysis of side and non-side populations isolated from A549 lung carcinoma cells cultivated under normoxic and hypoxic conditions.

Co-investigator of the project VEGA 1/0003/23: Changes in the regulation of BCRP transport protein expression and activity in relation to the proangiogenic and metastatic potential of cancer cells. Principal investigator: prof. RNDr. Peter Fedoročko, CSc. 2023 – 2026

Co-investigator of the project: „Nanočastice pre riešenie diagnosticko-terapeutických problémov s COVID-19 (NANOVIR)". Operational Programme Integrated Infrastructure, project “NANOVIR”, ITMS:313011AUW7, co-funded by ERDF. 01/2021 – 06/2023; Principal investigator: doc. RNDr. Adriana Zeleňáková, PhD.

Co-investigator of the project APVV-18/0125 Novel anthraquinones from natural sources for biomedical applications, 2019 –2023. Principal inestigator: prof. RNDr. Eva Čellárová, DrSc

Co-investigator of the project: Open scientific community for modern interdisciplinary research in medicine (OPENMED, ITMS2014+: 313011V455). 11/2019 - 6/2023

Co-investigator of the project VEGA 1/0022/19:Hypoxia and polymorphism of BCRP transporter as the factors affecting hypericin accumulation and efficiency in vitro and ex ovo, 2019 – 2022. Principal investigator: prof. RNDr. Peter Fedoročko, CSc.

International mobilities and visits
New and Advanced Proteomics Technologies workshop a Annual user meeting (EPIC-XS project) in Tartu, Estonia, University of Tartu (Estonia) and University of Cambridge, funded by EPIC-XS project, 26.-30. June 2022, EPIC-XS, project number 823839, funded by the Horizon 2020 programme of the European Union.
„ISAC LETF PRAGUE Cytometry Workshop 2019“, CLIP laboratories 2. LF UK a FN Motol Prague, Czech Republic, 11.-14. April2019, Erazmus+
Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic, Královopolská 135, 612 65 Brno-Žabovřesky, Czech Republic, 02/2016 – 05/2016, Erazmus+
Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic, Královopolská 135, 612 65 Brno-Žabovřesky, Czech Republic, 01/2015 – 04/2015, KVARK

Additional information

Awards
▪ Dean's Award for the scientific research activity of PhD. students for 2017, Faculty of Science of the University of Pavel Jozef Šafárik in Košice, Košice, 28 March 2018 ▪1st place at the Competition of Young Oncologists, Cancer Research Foundation, Martin, 7th March 2018 (category PhD student) ▪1st place and the price of “Ľudovít Drobnica in competition of young researchers in biochemistry and molecular biology”, Memorial of Ľudovít Drobnica IX, Danišovce, 12.-14. September 2017, Slovak Republic
Projects
1. EPIC-XS-0000051 (p.n. 823839, The European Proteomics Infrastructure Consortium providing access) funded by the Horizon 2020 programme of the European Union: ProSiPo (Proteomics of the Side Population): Comparative proteomic analysis of side and non-side populations isolated from A549 lung carcinoma cells cultivated under normoxic and hypoxic conditions. 2. Co-investigator of the project VEGA 1/0003/23: Changes in the regulation of BCRP transport protein expression and activity in relation to the proangiogenic and metastatic potential of cancer cells. Principal investigator: prof. RNDr. Peter Fedoročko, CSc. 2023 – 2026 3. Co-investigator of the project: „Nanočastice pre riešenie diagnosticko-terapeutických problémov s COVID-19 (NANOVIR)".Operational Programme Integrated Infrastructure, project “NANOVIR”, ITMS:313011AUW7, co-funded by ERDF. 01/2021 – 06/2023; Principal investigator: doc. RNDr. Adriana Zeleňáková, PhD. 4. Co-investigator of the project APVV-18/0125 Novel anthraquinones from natural sources for biomedical applications, 2019 –2023. Principal inestigator: prof. RNDr. Eva Čellárová, DrSc 5. Co-investigator of the project:Open scientific community for modern interdisciplinary research in medicine (OPENMED, ITMS2014+: 313011V455).11/2019 -6/2023
International collaboration
Central Laboratory of Proteomics (CEITEC) prof. RDNr. Zbyněka Zdráhal, Dr., Masaryk University in Brno - collaboration as a part of the EPIC-XS project. Institute of Biophysics of the Czech Academy of Sciences in Brno, Department of Cytokinetics (Mgr. Karel Souček, Ph.D.).

Further information


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