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Email:
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mariana.budovska@upjs.sk |
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Homepage:
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https://www.upjs.sk/PF/zamestnanec/mariana.budovska | |
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Faculty:
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PF UPJŠ
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Pavol Jozef Šafárik University in Košice, Faculty of Science
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Department:
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ÚCHV
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Institute of Chemistry
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Office:
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RB2O201 | |
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Phone:
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+421 55 234 2349 | |
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ORCID ID:
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https://orcid.org/0000-0003-0544-1289 |
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Overview of the responsibility for
the delivery, development and quality assurance of the study programme or its part
at the university in the current academic year
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Study programme: OCHd - Organic Chemistry - (Single degree study, Ph.D. III. deg., Full-Time form), study field: 17. - Chemistry, Ph.D. III. deg. degree
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Study programme: OCHm - Organic Chemistry - (Single degree study, master II. deg., Full-Time form), study field: 17. - Chemistry, master II. deg. degree
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Profile courses
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Heterocyclic compounds - OCHm - Organic Chemistry - (Single degree study, master II. deg., Full-Time form), master II. deg. degree
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Nitrogen heterocycles - OCHd - Organic Chemistry - (Single degree study, Ph.D. III. deg., Full-Time form), Ph.D. III. deg degree
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Selected publications
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ADC 1. Očenášová, L.; Budovská, M.; Očenáš, P.; Tomášková, N.; Bago Pilátová, M.; Mojžiš, J.: The first synthesis of natural alkaloid capparine A. Tetrahedron, 2021, 77, 1-12, art.no. 131772. IF 2,233, Q2, Citations: 3 |
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ADC 2. Budovská, M.; Baláž, M.; Mezencev, R.; Tischlerová, V.; Zigová, M.; Mojžiš, J.: Design, synthesis and anticancer activity of trifluoromethylphenylamino substituted spiroindoles. J. Fluorine Chem., 2018, 216, 24-32. IF 2.332, Q2, Citations: 5 |
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ADC 3. Budovská, M.; Tischlerová, V.; Mojžiš, J.; Harvanová, M.; Kozlov, O.; Gondová, T.; Tomášková, N.: 2′-Aminoanalogues of the cruciferous phytoalexins spirobrassinin, 1-methoxyspirobrassinin and 1-methoxyspirobrassinol methyl ether: Synthesis and anticancer properties. Tetrahedron, 2017, 73, 6356-6371. IF 2,233, Q2, Citations: 6 |
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ADC 4. Solárová, Z.; Kello, M.; Varinská, L. Budovská, M.; Solár, P.: Inhibition of heat shock protein (Hsp) 90 potentiates the antiproliferative and pro-apoptotic effects of 2-(4′fluoro-phenylamino)-4H-1,3-thiazine[6,5-b]indole in A2780cis cells. Biomed. Pharmacother., 2017, 85, 463-471. IF 4.545, Q1, Citations: 3 |
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ADC 5. Tischlerová, V.; Kello, M.; Budovská, M.; Mojžiš, J.: Indole phytoalexin derivatives induce mitochondrial-mediated apoptosis in human colorectal carcinoma cells. World J. Gastroentero., 2017, 23, 4341-4353. IF 3.875, Q1, Citations: 13 |
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Selected projects
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2020-2022 Co-researcher of the grant VEGA no. 1/0138/20: Intelligent nanoconjugates based on nanoparticles and DNA aptamers. Project leader: doc. RNDr. Viktor Víglaský, Ph.D. |
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2023-2026 Co-researcher of the grant VEGA no. 1/0347/23: Nanoconjugates from non-canonical DNA structural motifs: the basic compound of biosensors. Project leader: doc. RNDr. Viktor Víglaský, PhD. |
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2022-2025 Co-researcher of the grant VEGA no. 1/0037/22: Development and research of new pharmacophores based on acridine and coumarin with antimicrobial and antitumor effects. Project leader: prof. RNDr. Mária Kožurková, CSc. |
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International mobilities and visits
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University of Turku, Turku, Finland, 1.7.2009-30.11.2009, CIMO Fellowships, Finnish National Agency for Education (EDUFI)
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Université Louis Pasteur, ECPM, Laboratoire de Stéréochimie, Strasbourg, France, 1.2.2005–30.6.2005, Socrates-Erasmus
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Awards
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2006 - Prize of rector awarded for excellent study results
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Projects
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Project leader: 1. VEGA 1/0954/12: Spirocyclization reactions of indole phytoalexin brassinin, its derivatives and analogs, (2012-2015). 2. VVGS UPJŠ 37/07-08: Synthesis of indole phytoalexin spirobrassinin and its N-analogues as potential anticancer agents, (2007-2008). 3. VVGS PF UPJŠ 13/2011/Ch: Stereoselective synthesis of spiroindole phytoalexin (S)-(-)-spirobrassinin and study of synthesis 2-alkyl- and 2-arylanalogs of 1-methoxyspirobrassinol methyl ether,, (2011). 4. VVGS PF UPJŠ 2012-31: Spirocyclization reactions of brassinin and its 1-substituted derivatives and study of synthesis 5-bromo derivatives of spiroindole phytoalexins, (2012-2013). 5. VVGS UPJŠ 2013-96: Synthesis and anticancer activity of aminoanalogs of indole phytoalexins, (2013-2014). 6. VVGS UPJŠ 2016-248: Syntheses of 5-fluoro-derivatives and 2´-aminoanalogs of indole phytoalexins as new antitumor active substances, (2016-2017). Co-researcher: 1. APVV-0514-06: 1-Methoxyindole phytoalexins and their analogues as a new type of compounds with antitumor activity, (2007-2009), Project leader: doc. RNDr. Peter Kutschy, CSc. 2. VEGA 1/3553/06: Stereoselective synthesis of spiroindoline phytoalexins and their analogs, (2006-2008), Project leader: doc. RNDr. Peter Kutschy, CSc. 3. VEGA 1/0406/10: Elektrophilic-nucleophilic difunctionalization of indole: Synthesis and interconversion of spiroindolinethiazolines and thiazinoindoles with anticancer activity, (2010-2011), Project leader: doc. RNDr. Peter Kutschy, CSc. 4. VEGA 1/0322/14: Indole phytoalexins - mechanism of the antiproliferative activity (2014-2016), Project leader: prof. MVDr. Ján Mojžiš, DrSc. 5. VEGA 1/0138/20: Intelligent nanoconjugates based on nanoparticles and DNA aptamers, (2020-2022), Project leader: doc. RNDr. Viktor Víglaský, PhD. 6. VVGS UPJŠ 52/12-13: Stereoselective synthesis of hybrid molecules with embedded spiroindoline[3,5´]thiazoline skeleton using antitumor active allobetulin, (2012-2013), Project leader: RNDr. Lucia Tomášová
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International collaboration
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doc. RNDr. Roman Mezencev, PhD.: Georgia Institute of Technology, School of Biological Sciences, Atlanta, USA. Cooperation in the field of Structure-Activity Relationships of synthesized compounds.
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