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Email:
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rastislav.jendzelovsky@upjs.sk |
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Homepage:
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https://www.upjs.sk/PF/zamestnanec/rastislav.jendzelovsky/ | |
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Faculty:
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PF UPJŠ
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Pavol Jozef Šafárik University in Košice, Faculty of Science
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Department:
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ÚBEV
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Institute of Biology and Ecology
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Office:
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RB1O104 | |
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Phone:
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+421 55 234 1199 | |
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ORCID ID:
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https://orcid.org/0000-0001-6338-0723 |
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Overview of the responsibility for
the delivery, development and quality assurance of the study programme or its part
at the university in the current academic year
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Study programme: Biology: the person responsible for teaching of the profile subject, study field: Biology, Bachelor degree
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Study programme: Molecular cytology and genetics: the person responsible for teaching of the profile subject, study field: Biology, Doctoral degree
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Profile courses
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Cytology (ÚBEV/CYT1/15) - Biology, Bachelor degree
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Molecular cytology (ÚBEV/MCYT/22) - Molecular cytology and genetics, Doctoral degree
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Selected publications
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ID: 53505/ADC: Hypericin affects cancer side populations via competitive inhibition of BCRP / Vargová, Jana; Mikeš, Jaromír; Jendželovský, Rastislav; Mikešová, Lucia; Kuchárová, Barbora; Čulka, Ľubomír; Fedr, Radek; Remšík, Ján; Souček, Karel; Kozubík, Alois; Fedoročko, Peter. – DOI 10.1016/j.biopha.2018.01.074. – WOS CC ; SCOPUS ; CCC In: Biomedicine & Pharmacotherapy. - ISSN 0753-3322. – ISSN (online) 1950-6007. – no. 99 (2018), p. 511-522. |
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ID: 115863/ADC: Breast cancer resistance protein is the enemy of hypericin accumulation and toxicity of hypericin-mediated photodynamic therapy / Jendželovský, Rastislav; Jendželovská, Zuzana; Kuchárová, Barbora; Fedoročko, Peter. – DOI 10.1016/ j.biopha.2018.11.084. – WOS CC ; SCOPUS ; CCC In: Biomedicine & Pharmacotherapy. - ISSN 0753-3322. - ISSN (online) 1950-6007. – no. 109 (2019), p. 2173-2181. |
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ID: 130192/ADC: Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane / Majerník, Martin; Jendželovský, Rastislav; Babinčák, Marián; Košuth, Ján; Ševc, Juraj; Tonelli Gombalová, Zuzana; Jendželovská, Zuzana; Buríková, Monika; Fedoročko, Peter. – DOI 10.3390/ ijms20123004. – WOS CC ; SCOPUS ; CCC In: International journal of molecular sciences. - ISSN 1661-6596. – ISSN (online) 1422-0067. – Vol. 20, no. 12 (2019), art. no. 3004, p. [1-24]. |
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ID: 251151/ADM: Death receptor 5 (Tnfrsf10b) is upregulated and trail resistance is reversed in hypoxia and normoxia in colorectal cancer cell lines after treatment with skyrin, the active metabolite of hypericum spp. / Babinčák, Marián; Jendželovský, Rastislav; Košuth, Ján; Majerník, Martin; Vargová, Jana; Mikulášek, Kamil; Zdráhal, Zbyněk; Fedoročko, Peter. – DOI 10.3390/cancers13071646. – WOS CC ; SCOPUS In: Cancers. - ISSN (online) 2072-6694. – Vol. 13, no. 7 (2021), art.no. 1646., p. [1-30]. |
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ID: 1051326/ADC: New findings on the action of hypericin in hypoxic cancer cells with a focus on the modulation of side population cells / Buľková, Viktória [Autor, 35%] ; Vargová, Jana [Korešpondenčný autor, 22%] ; Babinčák, Marián [Autor, 10%] ; Jendželovský, Rastislav [Autor, 10%] ; Zdráhal, Zbyněk [Autor, 5%] ; Roudnický, Pavel [Autor, 5%] ; Košuth, Ján [Autor, 3%] ; Fedoročko, Peter [Autor, 10%]. – [recenzované]. – DOI 10.1016/j.biopha.2023.114829. – WOS CC ; SCO ; CCC In: Biomedicine & pharmacotherapy [textový dokument (print)] [elektronický dokument] . – Paríž (Francúzsko) : Elsevier. – ISSN 0753-3322. – ISSN (online) 1950-6007. – Roč. 2023, č. 163 (2023), art.no. 114829, s. [1-15]. |
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Selected projects
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Project code: ITMS2014+ 313011V455 Supported by the Fund: European Regional Development Fund Name of the project: Open scientific community for modern interdisciplinary research in medicine (OPENMED) Implementation period: 11/2019 - 6/2023 Position in the project: co-investigator of the project Project link: https://www.upjs.sk/pracoviska/ccvapp/podpora-projektov/grantove-schemy/ii/OPENMED/ |
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Slovak Research and Development Agency under contract no. APVV-18-0125 Name of the project: Novel anthraquinones from natural sources for biomedical applications Implementation period: 7/2019 - 6/2023 Position in the project: co-investigator of the project Project link: https://www.upjs.sk/prirodovedecka-fakulta/ustav/ubev/apu/kg/projekty/ |
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The Scientific Grant Agency of the Ministry of Education of the Slovak Republic under the contact no. VEGA 1/0022/19 Name of the project: Hypoxia and polymorphism of BCRP transporter as the factors affecting hypericin accumulation and efficiency in vitro and ex ovo Project implementation: 01/2019 - 12/2022 Position in the project: deputy project manager Project link: https://www.upjs.sk/prirodovedecka-fakulta/ustav/ubev/apu/kbb/projekty/ |
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Name of the project: Bioactive Substances Research Team for Biomedical Applications (Bioaktiv) Position in the project: co-investigator of the project Project link: https://www.upjs.sk/ aktualne-spravy/21934/ |
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International mobilities and visits
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Czech society for analytical cytometry, Královopolská 2590/135, Žabovřesky, 612 00 Brno, Czech republic, 12-14.4.2019, Erasmus plus
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Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65 Brno, Czech republic, 25.2.2009-8.3.2009, work stay
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Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65 Brno, Czech republic, 1.9.2007-1.3.2008, work stay
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Organisational activities
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■ Entrusted with management of the Department of cell biology - Pavol Jozef Šafárik University in Košice, Faculty of Science, Institute of biology
and ecology, od 3.5.2024
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■ Academic senate - Pavol Jozef Šafárik University in Košice, Faculty of Science, od 11.3.2015
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■ Česká společnost pro analytickou cytometrii, z.s. (ČSAC) - Česká společnost pro analytickou cytometrii, z.s. (ČSAC), Královopolská 135, 612 65
Brno, Česká republika, od roku 2015
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■ Odborný seminár „Prietoková cytometria – od základov po aplikácie a BDB – digitálna
prietoková cytometria“ (Organizátori: BioG, BD Biosciences, za ÚBEV: Jana Vargová,
Rastislav Jendželovský, Viktória Buľková). - Univerzita Pavla Jozefa Šafárika v Košiciach, Prírodovedecká fakulta, Ústav biologických
a ekologických vied, 12.6.2019-13.6.2019
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■ Aktívna účasť na podujatí „Noc výskumníkov“ formou vedeckého stánku s názvom „Bunka
pod mikroskopom“ (2018, Košice, Atrium Optima). - Univerzita Pavla Jozefa Šafárika v Košiciach, Prírodovedecká fakulta, Ústav biologických
a ekologických vied, 28.9.2018 (9:00-21:00)
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Awards
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■ In 2015 he was awarded by the dean of Faculty of Science, Pavol Jozef Šafárik University in Košice for the significant results in science and research. ■ In 2012 and 2014 he was awarded by the Slovak Cancer Research Foundation in Young oncologist competition in the field of general and clinical oncology research. ■ In 2007 he was awarded by "Czech society for analytical cytology" for the presentation of the results at conference Analytical cytometry IV. in Brno, Czech Republic
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Projects
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■■■ Project title: Open scientific community for modern interdisciplinary research in medicine (OPENMED, ITMS2014+: 313011V455), co-investigator of the project The aim of the project is to solve selected problems of diagnosis and treatment of oncological, cardiovascular and viral diseases, CNS diseases and diseases of the musculoskeletal system with a unique use of the potential of the partners in the project. One of the main aims of the project is to examine the response of cancer stem cells to both the conventional form of therapy (depending on the nature of the tumour) and selected types of chemotherapeutics that will be transported by DNA/RNA nanoparticles to achieve a synergistic effect. ■■■ Project title: Changes in the regulation of BCRP transport protein expression and activity in relation to the proangiogenic and metastatic potential of cancer cells (VEGA 1/0003/23), co-investigator of the project, deputy project manager. The goal of proposed project is to reveal the mechanisms of BCRP regulation in cancer cells after hypericin action and to verify their involvement in the angiogenesis and epithelial-mesenchymal transition. Understanding the regulatory mechanisms of resistance can help to increase the effectiveness of therapeutic approaches in oncology. ■■■ Project title: Novel anthraquinones from natural sources for biomedical applications (APVV-18-0125), co-investigator of the project The main objectives of this project are to contribute to the knowledge on regulation of biosynthesis of the studied anthraquinones based on genomic/transcriptomic and metabolomic analyses and bring more understanding to the crosstalk between the endophytic microorganisms and their plant hosts with perspective of their biotechnological production; to determine (anti)genotoxic, eventually DNA-protective effect and influence on cell cycle dynamics and antioxidant properties of the studied compounds and to accomplish a pilot study of their cytotoxic effect on cancer cell lines and avian embryo chorioallantoic membranes and modulation effect on interactions between cancer and immune cells with perspective use in anticancer therapy. ■■■ Project title: Hypoxia and polymorphism of BCRP transporter as the factors affecting hypericin accumulation and efficiency in vitro and ex ovo (VEGA 1/0022/19), co-investigator of the project, deputy project manager. The presented project is focused on specification of the negative prognostic marker for the application of hypericin in (anticancer) photodynamic therapy or photodynamic diagnosis. The main objectives of project are to specify the mutations in ABCG2 gene resulting in amino acid substitutions in BCRP protein and to determine the effect of non-photoactivated hypericin under hypoxic conditions on the level and activity of ABC transporters, and the incidence of putative cancer stem cells. The third aim of the project is to find out if non-photoactivated hypericin can inhibit the selected proangiogenic factors of tumours formed on chorioallantoic membrane.
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Other
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■ member of the departmental committee for doctoral studies in the field of study Molecular Cytology and genetics at the Faculty of Science, Pavol Jozef Šafárik University in Košice ■ member of the departmental committee for bachelor studies in the field of study Biology at the Faculty of Science, Pavol Jozef Šafárik University in Košice ■ member of the evaluation committee for the Young Oncologists Competition for the best work in the field of oncology research in the category "Young researcher under 35" ■ member of the expert jury of the Student Scientific Conference at the Faculty of Science, Pavol Jozef Šafárik University in Košice
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