PF

RNDr. Zuzana Kudličková, PhD.   SK

Email:
zuzana.kudlickova@upjs.sk
Homepage:
https://www.upjs.sk/PF/zamestnanec/zuzana.kudlickova
Faculty:
PF UPJŠ - Pavol Jozef Šafárik University in Košice, Faculty of Science
Department:
ÚCHV - Institute of Chemistry
Office:
RC0O111
Phone:
+421 55 234 1219, 2377
ORCID ID:
0000-0002-5310-6744
Zuzana Kudličková, PhD., is a doctor of organic chemistry at the Faculty of Science of Pavol Jozef Šafárik University in Košice. She works at the Institute of Chemistry as a researcher, at the academic workplace Laboratory of Nuclear Magnetic Resonance. As part of hes research activities, she is engaged in the synthesis and study of antiproliferative properties of natural substances (and their analogues) containing the indole skeleton. In cooperation with the Institute of Geotechnics, she deals with the application of mechanochemistry in the synthesis of indole derivatives of natural substances, chalcones. She participates in solving several basic and applied research projects.

Higher education and further qualification growth
Second degree of higher education:
Faculty of Science, Pavol Jozef Šafárik University in Košice, 2001, Chemistry
Third degree of higher education:
Faculty of Science, Pavol Jozef Šafárik University in Košice, 2006, Organic Chemistry

Research /art/ teacher profile

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Profile courses
ÚCHV/MUS/03 Structure determination - spectroscopic methods - Chemistry, I. - Bachelor degree
ÚCHV/MUSU/21 Structure determination - spectroscopic methods - Joint degree study, I. - Bachelor degree
Selected publications

Kudličková, Z., Takáč, P., Sabolová, D., Vilková, M., Baláž, M., Béres, T., Mojžiš, J. (2021). Novel 1-methoxyindole- and 2-alkoxyindole-based chalcones: design, synthesis, characterization, antiproliferative activity and DNA, BSA binding interactions. Medicinal Chemistry Research, 30(4), 897–912. Citation: 2, 5-Year Impact Factor: 1.98, WOS quartile Chemistry, Medicinal, Q4

Kuruc, T., Kello, M., Petrova, K., Kudlickova, Z., Kubatka, P., & Mojzis, J. (2021). The newly synthetized chalcone L1 is involved in the cell growth inhibition, induction of apoptosis and suppression of epithelial-to-mesenchymal transition of HeLa cells. Molecules, 26(5), 1–27. Citations: 3, 5-Year Impact Factor: 4.588 WOS kvartil Chemistry, Multidisciplinary, Q2

Baláž, M., Kudličková, Z., Vilková, M., Imrich, J., Balážová, Ľ., Daneu, N. Mechanochemical synthesis and isomerization of N-substituted indole-3-carboxaldehyde oximes. Molecules 24 (2019) art. no. 3347. Citations: 9, 5-Year Impact Factor: 3.589, WOS quartile Chemistry, Multidisciplinary, Q2

Takac, P., Kello, M., Bago, M., Kudlickova, Z., Vilkova, M., Slepcikova, P., Petik, P., Mojzis, J. New chalcone derivative exhibits antiproliferative potential by inducing G2 / M cell cycle arrest , mitochondrial-mediated apoptosis and modulation of MAPK signalling pathway. Chemico-Biological Interactions, (2018) 292, 37–49. Citations: 21, 5-Year Impact Factor: 4,611; WOS quartile Biochemistry, Molecular Biology, Q2; Pharmacology, Pharmacy, Q1

Michalková R., Kello, M., Kudlickova, Z., Gazdová M., Mirossay M., Mojžišova g., Mojžiš J. Programmed Cell Death Alterations Mediated by Synthetic Indole Chalcone Resulted in Cell Cycle Arrest, DNA Damage, Apoptosis and Signaling Pathway Modulations in Breast Cancer Model. Pharmaceutics (2022) 14, art. no. 503, Citations: 3, 5-Year Impact Factor: 6.734; WOS quartile Pharmacology, Pharmacy, Q1

Selected projects

VEGA project no. 2/0044/18 High-energy milling for the synthesis of nanomaterials by a bio-approach and selected environmental applications, member of the research team

VEGA project no. 2/0112/22 High-energy grinding of egg waste based on calcite and selected plants for the preparation of nanocrystalline minerals and environmental applications, member of the research team

Additional information

Projects
VEGA 2/0112/22: High-energy grinding of egg waste based on calcite and selected plants for the preparation of nanocrystalline minerals and environmental applications, member of the research team KEGA008UPJŠ-4/2023: Innovation of NMR spectroscopy courses education in chemistry study field, member of the research team APVV SK-CZ-RD-21-0068: Monolithic, hierarchically porous MOF-carbon composites for environmental applications, member of the research team
International collaboration
Department of Pharmacology, Faculty of Medicine, UPJŠ - antiproliferative activity of compounds, study of the mechanism of action Department of Mechanochemistry, Institute of Geotechnics SAS - mechanochemical synthesis of organic compounds Georgia Institute of Technology, School of Biological Sciences), Atlanta, USA - antitumor activity of natural substances, diseases associated with protein aggregation

Further information


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